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BRD4 degrader AT1

CAS No. 2098836-45-2

BRD4 degrader AT1( BRD4 PROTAC AT1 )

Catalog No. M13321 CAS No. 2098836-45-2

BRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BRD4 degrader AT1
  • Note
    Research use only, not for human use.
  • Brief Description
    BRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.
  • Description
    BRD4 degrader AT1 is a highly selective BED4 degrader (PROTAC), exhibits highly selective depletion of BRD4 in cells with negligible activity against BRD2 and BRD3.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BRD4 PROTAC AT1
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    2098836-45-2
  • Formula Weight
    972.68
  • Molecular Formula
    C48H58ClN9O5S3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL 102.81 mM
  • SMILES
    CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(C)=O)C(C)(SCCCCCCNC(C[C@H]4C5=NN=C(C)N5C(SC(C)=C6C)=C6C(C7=CC=C(Cl)C=C7)=N4)=O)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1
  • Chemical Name
    (2S,4R)-1-((R)-2-acetamido-3-((6-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)hexyl)thio)-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.
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